World number eight Rafael Nadal is out of the US Open after losing a five-set, third-round thriller to Italian Fabio Fognini at Flushing Meadows.Spaniard Nadal, 29, the winner of 14 Grand Slam titles, won the first two sets, but lost the next three as he was beaten 3-6 4-6 6-4 6-3 6-4.It is the first time that the double US Open winner has lost in a Grand Slam having been two sets up.World number 32 Fognini, 28, faces Spain`s Feliciano Lopez in round four.