Luis Enrique has left his role as Spain manager after they were knocked out of the World Cup by Morocco.
The 52-year-old took charge of the side in 2018 and guided Spain to the Euro 2020 semi-finals.
The Spanish Football Federation (RFEF) said a "new project" should start but did not put a time frame on when a new boss would be announced.
"We would like to thank Luis Enrique and his entire coaching staff," the RFEF said in a statement.
The former Spain midfielder stepped away from his role for a short period in 2019 because his late daughter had been diagnosed with bone cancer, before returning for the side's impressive Euros run in the tournament that was delayed by a year because of the Covid-19 pandemic.
Spain were knocked out of the Euros by eventual champions Italy after their semi-final went to a penalty shootout.
They thrashed Costa Rica 7-0 in their opening group game of the World Cup but their possession-based game saw them accused of being "boring" as they drew 1-1 with Germany and lost 2-1 to Japan.
On Tuesday, Spain were held to a goalless draw by Morocco before again losing a penalty shootout as they were knocked out.
Source: BBC