Bangladesh ace all-rounder Shakib Al Hasan took four wickets to propel the Tigers restrict West Indies to 122 in the opener of the three-match ODI series.
Batting first at Sher-e-Bangla National Cricket Stadium in Mirpur on Wednesday, the Windies were all out in 32.2 overs.
For them, the highest score, 40, came from Kyle Mayers' bat, and Rovman Powell scored the second highest, 28 runs.
For the host, Shakib Al Hasan bagged four wickets for 8 runs, debuted Hasan Mahmud 3 for 28, Mustafizur Rahman 2 for 20 and Mehidy Hasan 1 for 29.
Earlier, Bangladesh captain Tamim Iqbal won the toss and opted to field first.
Bangladesh XI: Tamim Iqbal (capt), 2 Liton Das, 3 Nazmul Hossain Shanto, 4 Shakib Al Hasan, 5 Mushfiqur Rahim (wk), 6 Mahmudullah, 7 Soumya Sarkar, 8 Mehidy Hasan Miraz, 9 Hasan Mahmud, 10 Mustafizur Rahman, 11 Rubel Hossain.
West Indies XI: 1 Sunil Ambris, 2 Joshua da Silva (wk), 3 Andre McCarthy, 4 Nkrumah Bonner, 5 Jason Mohammed (capt), 6 Rovman Powell, 7 Kyle Mayers, 8 Akeal Hosein, 9 Raymon Reifer, 10 Alzarri Joseph, 11 Chemar Holder.